Biomarker Framework
Three primary domains
of biological assessment
Structural Integrity
Collagen structure is defined not only by production, but by balance. Biovève evaluates both synthesis and degradation, along with regulatory control, to understand whether the skin is maintaining or losing structural integrity over time.PMID 26562801
Inflammatory Balance
Chronic low-grade inflammation is a key driver of premature skin aging. These markers provide insight into the skin's inflammatory environment — often before visible symptoms appear.PMID 30046148
Regeneration & Repair
Skin aging is closely linked to cellular energy, regeneration capacity, and longevity signaling. By assessing these markers, Biovève captures signals related to repair, stress response, and long-term cellular function.
Biomarker Panel
A panel of nine biomarkers
Selected for their relevance to key biological pathways involved in skin aging and resilience. PMID 14648584PMID 9358139PMID 29249689PMID 18419796
- 01MMP-1Collagen Dynamics
Matrix metalloproteinase-1. A primary collagen-degrading enzyme — elevated levels indicate accelerated structural breakdown of the dermal matrix.
- 02TIMP-1Collagen Dynamics
Tissue inhibitor of matrix metalloproteinases. Regulates collagen degradation — the balance between MMP activity and TIMP-1 reflects structural stability.
- 03MMP-2Collagen Dynamics
Degrades structural components of the basement membrane — associated with deeper matrix remodeling and loss of skin density.
- 04CFDInflammation Load
Complement Factor D. Involved in the complement system's inflammatory cascade — elevated levels indicate a heightened inflammatory environment.
- 05TGF-β1Inflammation / Regeneration
A key regulator of collagen synthesis and tissue repair — plays a central role in maintaining dermal structure and recovery capacity.
- 06NAD⁺Cellular Longevity
Nicotinamide adenine dinucleotide. Essential for cellular energy metabolism and DNA repair — declines significantly with biological age.
- 07SIRT1Cellular Longevity
A longevity-associated protein regulating cellular stress response and repair — functionally linked to NAD⁺ levels and aging resilience.
- 08GDF11Regeneration & Renewal
Growth differentiation factor associated with systemic rejuvenation and tissue regeneration — reflects renewal potential.
- 09ApoDBarrier & Oxidative Stress
Apolipoprotein D. Involved in lipid transport and oxidative stress response — supports barrier integrity and cellular protection.
Systems-Based Interpretation
"Biological markers
do not operate independently."PMID 21164525
Biovève applies a systems-based approach that evaluates the relationships between pathways — such as the balance between collagen degradation and synthesis, or the interaction between inflammatory load and repair capacity.
This enables a more contextual and physiologically relevant interpretation of the skin's current state — capturing dynamic processes that are not visible at the surface level.
From Signal to Action
Skin is not only
what you apply.
Topical
Formulation alignment
Biovève maps skincare formulations against individual biomarker profiles — expressing compatibility through structured, percentage-based indicators rather than assigning fixed skin “types.”
Nutritional
Internal support mapping
Effective skin longevity requires alignment from both the outside and within. Nutritional and supplemental support is mapped to individual biomarker profiles — because biological signals reflect both external and internal influences.
Biomarker patterns are interpreted through a continuously evolving data layer that evaluates how different product formulations — both topical and nutritional — may align with individual biological profiles. Instead of assigning fixed skin types, Biovève maps biological signatures against product compositions.
A non-diagnostic, decision-support framework
Biovève does not provide medical diagnosis or treatment. It operates as a research and recommendation platform — translating biological data into decision-support insights that help individuals navigate available skincare and supplement options with greater clarity.
Because understanding biology changes how decisions are made.
- 01
Barabási AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011 Jan;12(1):56–68. doi: 10.1038/nrg2918.
PMID 21164525 - 02
Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997 Nov 13;337(20):1419–28. doi: 10.1056/NEJM199711133372003.
PMID 9358139 - 03
Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018 Oct;14(10):576–590. doi: 10.1038/s41574-018-0059-4.
PMID 30046148 - 04
Ganfornina MD, Do Carmo S, Lora JM, et al. Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell. 2008 Aug;7(4):506–15. doi: 10.1111/j.1474-9726.2008.00395.x.
PMID 18419796 - 05
Gardner J, Ghorpade A. Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system. J Neurosci Res. 2003 Dec 15;74(6):801–6. doi: 10.1002/jnr.10835.
PMID 14648584 - 06
Theocharis AD, Skandalis SS, Gialeli C, Karamanos NK. Extracellular matrix structure. Adv Drug Deliv Rev. 2016 Feb 1;97:4–27. doi: 10.1016/j.addr.2015.11.001.
PMID 26562801 - 07
Yoshino J, Baur JA, Imai SI. NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab. 2018 Mar 6;27(3):513–528. doi: 10.1016/j.cmet.2017.11.002.
PMID 29249689
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